Endocrine Abstracts

Aims: To look at the demographics, biochemistry, treatments used, clinical characteristics associated with radioiodine (RI) treatment (including those with relapse) for thyrotoxicosis in our Endocrine clinic.Methods: Electronic records of all thyrotoxic patients between 2010 and 2012.Results: 144 patients, mean age 56 years (114 females)–106 Graves, 24 toxic adenoma (TA) and 14 multi nodular goitre (MNG). TPO antibody was posi...

Introduction: It is not known if non-alcoholic fatty liver disease (NAFLD) predates type 2 diabetes. We will study the prevalence of NAFLD in women with previous gestational diabetes (GDM), a population at ≥60% risk for the development of type 2 diabetes, while glucose tolerance is non-diabetic. It is not known if hepatic fat accumulation in NAFLD is disproportionate to fat accumulation in other tissues. We aim to study the association between fat in the liver and in tis...

Introduction: Treculia Africana (TA) has been used as an anti-inflammatory agent by the Yoruba people of West Africa and is also known to be a component of an ancient anti-diabetic remedy used in the Western and Middle belt areas of Nigeria. This study was conducted to investigate the anti-hyperglycemic property of the aqueous seed extract of Treculia Africana (TAE) and also to evaluate the potential of this extract in reversing the toxicity inflicted by expe...

Adrenal tuberculosis was first described by Thomas Addison in 1855, Isolated adrenal tuberculosis is rare and between represents 1–2% of the aetiologies of adrenal masses called expired incidentalomas. We report the case of a related Addison’s disease is a progressive adrenal tuberculosis which could benefit from exploration and a tomography monitoring on anti tuberculosis treatment. Patient aged 35 years presented himself to medical emergency with clinical surgical ...

Case History: An 84-year-old women presented to a psychiatric unit with a 5-month history of fluctuating confusion, paranoid behaviour, anxiety, reduced cognition and unsteadiness. There was no history of galactorrhoea, headache or visual field disturbance. Past medical history included hypertension, chronic kidney disease, congestive heart failure, premature menopause and hyperlipidaemia. She had been taking bendroflumethiazide, furosemide, mirtazepine and sulpiride. A CT hea...

Sy Sheehan or postpartal pituitary necrosis presents with symptoms and signs of hypopituitarisms. It is usually a consequence of complicate delivery followed by intensive uterine bleeding. Diagnosis can be delayed years after delivery, up to 20 years.We present a case of 51-year-old female patient. She was admitted in the department of neurology in the Emergency center, Belgrade, with disturbance of consciousness. Few days before she felt leg weakness an...

The aim of this study was to investigate the contribution of thyroid and parathyroid glands dysphunction to the arterial hypertension ethiology in elderly patients suffering from hronic renal failure.In 34 patients, average age of 67 years (range: 65–68), with glomerular filtration rate (GFR, 99mTcDTPA) <60 ml/min, as well as the creatinine clearence (Cockcroft) values between 60 and 30 ml/min, thyroid gland function was analys...

Twelve-month-old GK rats that showed glucose intolerance were compared with age matched Wistar rats. The concentrations of noradrenaline (NA), adrenaline (ADR) dopamine (DOP), Neuropeptide Y (NPY), and calcitonin gene-related peptide (CGRP) were measured in tissue samples. The objective was to assess whether glucose intolerance was associated with changes in the noradrenergic and peptidergic nerves innervating the tail artery (TA), seminal vesicle (SV) and corpus cavernosum (C...

Oestrogens act via oestrogen receptors (ER) that are expressed in a wide range of tissues including the vasculature, bone and gonads. Two ER genes known as ERalpha and ERbeta have been identified. In the human splice variants of ERbeta have been identified. ERs form both homodimers and heterodimers upon ligand binding. The aim of the present experiments was to study the functional activity of ERbeta1 (wild type) and ERbeta variant (ERbeta2) in single and double transfection as...

Introduction: Myxoid adrenocortical adenoma was described by Brown et al. in 2000 (1). Myxoid adrenal cortical adenoma with pseudo glandular structure is a particular histological variant and is extremely rare. Accurate diagnosis is based on the combined evaluation of clinical features, adrenal imaging, and pathological features. Immunohistochemical studies (cytokeratin, melan-A, USP10, chromogranin, vimentin) can distinguish adrenocortical adenoma from other retroperitoneal m...